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Abstract #3978

Myocardial fibrosis by CMR LGE in a large cohort of pediatric thalassemia major patients

Antonella Meloni 1 , Maddalena Casale 2 , Aldo Filosa 2 , Rosellina Rosso 3 , Antonino Vallone 4 , Gianluca Valeri 5 , Daniele De Marchi 1 , Vincenzo Positano 1 , Massimo Lombardi 1 , and Alessia Pepe 1

1 CMR Unit, Fondazione G.Monasterio CNR-Regione Toscana and Institute of Clinical Physiology, Pisa, Italy, 2 UOSD Centro per le Microcitemie, AORN Cardarelli, Napoli, Italy, 3 U.O. Talassemie ed Emoglobinopatie, Ospedale Ferrarotto CT Az. Osp. Universitaria Policlinico Vittorio Emanuele, Catania, Italy, 4 Istituto di Radiologia, Az. Osp. "Garibaldi" Presidio Ospedaliero Nesima, Catania, Italy, 5 Dipartimento di Radiologia, Azienda Ospedaliero-Universitaria Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona, Italy

In pediatric patients with thalassemia major myocardial fibrosis is not a rare finding to keep in mind in the cardiological management. When appropriate treatment has been administered since early childhood, CMR LGE can be postponed until 13 years of age. By the natural history of this large cohort of pediatric patients where HCV infection has been appropriately prevented, myocardial fibrosis seems to be associated with cardiac iron and high cardiac output.

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