Abstract #3985
Evaluation of the GAG content of articular cartilage in the knee joint using gagCEST: correlation to the gold-standard with multicompartmental biochemically analyzed GAG content
Martin Brix 1,2 , Vladimir Mlynarik 2 , Benjamin Schmitt 3 , Pavol Szomolanyi 2 , Gerhard Hobusch 1 , Florian Sevelda 1 , Stephan Puchner 1 , Sonja Walzer 1 , Reinhard Windhager 1 , Stephan Domayer 4 , and Siegfried Trattnig 2
1
Department of Orthopaedics, Medical
University of Vienna, Vienna, Austria,
2
High
Field MR Centre, Department of Biomedical Imaging and
Image-Guided Therapy, Medical University of Vienna,
Vienna, Austria,
3
Siemens
Australia, Australia,
4
Sonderkrankenanstalt
Zicksee, Austria
The purpose of this study was the comparison of
biochemically determined GAG content in knee joints of
human cadavers to gagCEST values. Therefore, the
condyles of four human cadavers were measured using
gagCEST. From each condyle, nine biopsies were taken
from a medial and lateral compartment and the GAG
content was measured in the lab. Regions of interest
were drawn manually corresponding to the biopsy areas. A
correlation coefficient of r = 0.863 was observed (p <
0.001). The excellent correlation between the MTRasym
and cartilage GAG content demonstrates the feasibility
of the technique.
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