Abstract #3990
In Vivo MR Computation of Whole Proximal Femur Mechanical Competence Using Micro-Finite Element Analysis Applied to High-Resolution 3T MRI of Proximal Femur Microarchitecture
Alexandra Hotca 1,2 , Chamith S. Rajapakse, PhD 3 , Henry Rusinek, PhD 4 , Stephen Honig, MD 5 , Ryan Brown, PhD 6 , Cem M. Deniz, PhD 6 , Ravinder R. Regatte, PhD 6 , and Gregory Chang, MD 1
1
Department of Radiology, NYU Langone Medical
Center, Center for Musculoskeletal Care, New York, NY,
United States,
2
Department
of Biological Sciences, CUNY-Hunter College, New York,
NY, United States,
3
Department
of Radiology, University of Pennsylvania School of
Medicine, Philadelphia, PA, United States,
4
Department
of Radiology, New York University School of Medicine,
New York, NY, United States,
5
Osteoporosis
Center, Hospital for Joint Diseases, NYU Langone Medical
Center, New York, NY, United States,
6
Department
of Radiology, NYU Langone Medical Center, Center for
Biomedical Imaging, New York, NY, United States
In this study, micro-finite element analysis (μFEA) is
applied to high-resolution 3T MR images of proximal
femur microarchitecture to quantitatively assess the
mechanical competence (stiffness) of the whole proximal
femur in vivo. Bone microarchitecture is understood to
be a critical determinant of bone strength. The results
of this study show that μFEA can be used to detect
reduced whole proximal femur stiffness in subjects with
osteoporotic fractures compared to controls without
fracture who do not differ by bone mineral density. This
warrants a larger study to confirm these trends.
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