gagCEST MRI: A potential biomarker for post-surgery follow-up of patients with anterior cruciate ligament reconstruction
Olgica Zaric 1 , Pavol Szomolanyi 1 , Vladimir Mlynarik 1 , Mark Schurz 2 , Stefanie Syre 2 , Thomas Tiefenbck 2 , Manuela Karner 1 , and Siegfried Trattnig 1
Department of Biomedical Imaging and
Image-guided Therapy, Medical University in Vienna,
Vienna, Austria, Austria,
Surgery Department, Medical University in Vienna,
Vienna, Austria, Austria
The aim of this study was to investigate the feasibility
of gagCEST imaging and T2* mapping in post-surgery
follow-up of biochemical and morphological properties of
reconstructed tissue in the patients with anterior
cruciate ligament substitution. Results showed an
increase of gagCEST effect (related to total
glycosaminoglycan content in the tissue) from early to
late post-surgery period, while T2* (related to collagen
architecture network) showed a significant decrease.
Based on this initial results, we conclude that gagCEST
has a great potential as biomarker in investigation of
properties of newly developed ligament tissue in
patients after ACL reconstruction.
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