Hyperpolarized 13C lactate as a substrate for in vivo metabolic studies in skeletal muscle
Jessica A.M. Bastiaansen 1 , Hikari A.I. Yoshihara 2,3 , Yuhei Takado 2,4 , Rolf Gruetter 1,5 , and Arnaud Comment 2
Laboratory of Functional and Metabolic
Imaging, EPFL, Lausanne, Switzerland,
of Physics of Biological Systems, EPFL, Lausanne,
Department of Cardiology, CHUV,
of Biological Geochemistry, EPFL, Lausanne, Switzerland,
of Radiology, University of Geneva and University of
Lausanne, Lausanne, Switzerland
Lactate is not merely an end product in skeletal muscle
metabolism but also an important metabolic intermediate.
Using hyperpolarized 13C MRS, lactate metabolism can be
investigated in real time, injected at physiological
concentrations leaving other oxidative processes
undisturbed. Here we investigated the use of
hyperpolarized 13C lactate as a substrate for metabolic
studies in skeletal muscle in vivo, in different
nutritional states. The herein proposed method allows
probing simultaneously both PDH activity and variations
in alanine tissue concentration, which are associated
with metabolic dysfunctions.
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