Application of prospective cardio-respiratory gating for simultaneous quantitative DCE-MRI of multiple mammary tumours in the mouse.
Veerle Kersemans 1 , Philip D Allen 1 , John S Beech 1 , Stuart Gilchrist 1 , Paul Kinchesh 1 , and Sean C Smart 1
Gray Institute for Radiation Oncology and
Biology, Department of Oncology, University of Oxford,
Oxford, United Kingdom
The application of prospective cardio-respiratory gating
for quantitative DCE-MRI of abdominal and thoracic
tumours was investigated. The method was made feasible
through the use of cardio-respiratory synchronisation
techniques in conjunction with RF calibrations and
accurate temporal sampling. As a result, multiple chest
tumours which are highly susceptible to motion
corruption during DCE-MRI protocols could be screened
simultaneously and classified using quantitative DCE-MRI
parameters in a manner that is compatible with
high-throughput operation. Moreover, volume imaging
permitted visualisation and analysis of multiple breast
tumours in the chest during the same acquisition,
avoiding operator dependent slice pre-selection errors.
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