Abstract #4078
QQ quantification analysis of DCE-MRI for Osteosarcoma
Junyu Guo 1 and Wilburn E Reddick 1
1
St Jude Children's Research Hospital,
Memphis, TN, United States
We present a quantile-quantile (QQ) plot quantification
method to measure the changes between the baseline and
the following DCE-MRI examinations on a single phase II
trial for pediatric osteosarcoma (OS) patients. The QQ
quantification analysis could generate five QQ
parameters to describe the different characteristics of
the change of histograms in tumors between two serial
DCE-MRI examinations. We found that the QQ
quantification could potentially provide very early
biomarkers for histologic response and event free
survival analysis, but the mean value of DCE-MRI
parameters in the tumors didnt provide such early
biomarkers in a statistical analysis of 31 OS patients.
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