DCE-MRI and DWI are Sensitive to Vascular Changes in Renal Cell Carcinoma Following Sunitinib Therapy
Dania Daye 1 , Anil Chauhan 1 , Sarah Englander 1 , Thomas Ferrara 1 , Colleen Redlinger 2 , Naomi Haas 2 , Hee-Kwon Song 1 , Stephen Keefe 2 , and Mark Rosen 1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
University of Pennsylvania, Philadelphia, PA, United
We compared the sensitivity of DCE-MRI and multi-B-value
DWI to detect changes in renal cell carcinoma tumor
physiology following initiation of anti-angiogenic
therapy with Sunitinib. Both DCE-MRI and DWI were able
to detect therapy-induced changes in tumor physiology.
Statistically significant decreases in tumor
permeability and plasma volume (DCE), and fast diffusion
component and perfusion fraction (DWI) were shown.
Positive correlations were identified between DCE and
DWI methods for quantifying baseline RCC tumor vascular
physiology, and for detecting vascular changes in RCC
tumors early after therapy. DWI can be used as a
non-contrast method of tumor vascular monitoring during
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