Diffusion weighted MR derived apparent diffusion co-efficient values as a biomarker for treatment response in breast cancer
Eimear Ann Joyce 1 , Sylvia A O'Keeffe 1 , Andrew Fagan 1,2 , Jason McMorrow 1 , Danielle Byrne 1 , John Kennedy 3 , and James F Meaney 1,2
Centre for Advanced Medical Imaging, St.
James's Hospital, Dublin 8, Dublin, Ireland,
College Dublin, Dublin 2, Ireland,
Directorate, St. James' Hospital, Dublin, Ireland
The purpose of this study was to evaluate the
performance of tumor apparent diffusion coefficient
(ADC) values in predicting response early in the course
of chemotherapy, for patients with breast cancer. We
also assessed the effect of tumor marker clip placement
on the ADC value. Our results confirm that changes in
ADC values early in the course of treatment can predict
treatment response. The gel-containing clip, used for
tumor marking prior to neoadjuvant chemotherapy, results
in a potential source of error when calculating ADC
tumor values and should be avoided when drawing tumor
regions of interest.
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