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Abstract #4091

Clinical Implementation of Slice Accelerated EPI-DSC MR Perfusion Weighted Imaging

Donald Robinson Cantrell 1 , Thomas Anthony Gallagher 1 , Bruce Spottiswoode 2 , Timothy Carroll 1,3 , Charles Fasanati 1 , and Dingxin Wang 4,5

1 Department of Radiology, Northwestern University, Chicago, IL, United States, 2 Cardiovascular MR R&D, Siemens Healthcare, Chicago, IL, United States, 3 Department of Biomedical Engineering, Northwestern University, Chicago, IL, United States, 4 Siemens Medical Solutions USA, Inc., Minneapolis, MN, United States, 5 CMRR, University of Minnesota, Minneapolis, MN, United States

Perfusion Weighted Imaging (PWI) provides functional information on the hemodynamic status of CNS malignancies. Dynamic Susceptibility Contrast (DSC) enhanced MRI is an implementation of PWI that rapidly acquires images following contrast administration. However, standard clinical DSC-MRI protocols have limited spatial coverage and temporal resolution. Our previous work demonstrated the feasibility of using Slice Accelerated Echo Planar Imaging (SA-EPI) for DSC-MRI measurements in healthy volunteers. We now report the first large-scale clinical implementation of this promising new protocol for the evaluation of CNS malignancies. Faster data acquisition achieved with SA-EPI allows for increased spatial coverage while maintaining the required temporal resolution.

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