Towards quantitative T2- and ADC-mapping in prostate using diffusion weighted 3D DESS MRI
Isabel Dregely 1 , Daniel JA Margolis 1 , Kyung H Sung 1 , and Holden H Wu 1
University of California Los Angeles, Los
Angeles, California, United States
The purpose of this work was to apply diffusion weighted
3D DESS MRI to prostate imaging with the goal to achieve
simultaneously quantitative T2- and ADC-mapping.
Diffusion weighted DESS in the prostate is challenging
due to motion, which limits SNR especially on the
diffusion weighted echo-signal. Therefore only moderate
diffusion gradient moments could be applied. Preliminary
results in a healthy volunteer showed that quantitative
T2 and ADC-values were within expected range for healthy
prostate. Monte Carlo simulations showed good accuracy
and precision for T2, however less for ADC-mapping.
Simulated scenarios showed that improving SNR and/or
diffusion sensitivity will improve quantification.
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