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Abstract #4176

CHARACTERIZATION OF THALAMIC FUNCTIONAL COMPONENTS AND THEIR CONNECTIONS WITH CEREBRAL CORTEX : A DTI AND RS fMRI STUDY

Chiara Mastropasqua 1,2 , Marco Bozzali 1 , Giovanni Giulietti 1 , Giacomo Koch 3 , and Mara Cercignani 1,4

1 Neuroimaging Laboratory, IRCCS Santa Lucia, Rome, Italy, 2 Trieste University, Rome, Italy, 3 Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia, Rome, Italy, 4 Clinical Imaging Sciences Centre - University of Sussex, Brighton and Sussex Medical School, Brighton, United Kingdom

With the aim of comparing thalamo-cortical functional and structural connections, we used independent component analysis of resting state (RS) fMRI data to detect thalamic functional components at rest. Next, we used these thalamic components as seeds for RS seed based analysis and probabilistic tractography to identify cortical regions structurally and functionally connected with each thalamic components. The results were visually compared to cross-validate these two commonly used approaches. These two methods yield partially consistent results: the partial overall correspondence between structural and functional connections suggests that they provide complementary information.

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