Enhanced resting-state functional connectivity in spatial navigation networks after targeted transcranial direct current stimulation
Venkatagiri Krishnamurthy 1 , Kaundinya S Gopinath 1 , Gregory S Brown 2 , and Benjamin M Hampstead 2,3
Dept of Radiology and Imaging Sciences,
Emory University, Atlanta, GA, United States,
of Rehabilitation Medicine, Emory University, Atlanta,
GA, United States,
VAMC RR&D Center of Excellence in Visual and
Neurocognitive Rehabilitation, Decatur, GA, United
Spatial navigation ability declines in the elderly, and
in Alzheimers disease. Enhancing navigation skills will
result in functional improvement in these populations.
Transcranial direct current stimulation (tDCS) can be
used to modulate cortical excitability and brain
cognition. In this preliminary study, we examined
resting state functional connectivity (rsFC) in spatial
navigation networks with functional MRI, after
tDCS-based excitation of appropriate brain regions. RsFC
among a number of areas involved in spatial navigation
increased significantly after tDCS. The results can be
employed to evolve a framework for evoking plastic
reparatory changes in brain networks through tDCS and
monitoring them with rsFMRI.
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