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Abstract #4194

Increased gray matter density in parallel with increased connectivity in Parkinson disease

Mihaela Onu 1 , Liviu Badea 2 , and Adina Roceanu 3

1 Medical Imaging, Clinical Hospital "Prof. dr. Th. Burghele", Bucharest, Romania, 2 National Institute for Research in Informatics, Bucharest, Romania, 3 University Emergency Hospital Bucharest, Bucharest, Romania, Romania

We hypothesized that, in Parkinson disease (PD), gray matter density and functional cerebral connectivity might develop compensatory behaviors in response to the damaged motor control loops. Using VBM and rsfmri analyses, we found a gray matter thalamic enlargement in parallel with increased connectivity at the basal ganglia/thalamic level which may reflect a compensatory effect in response to the damaged motor control loops.

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