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Abstract #4196

CBF-based Modular Architecture Derived from ASL MRI

Feng-Xian Yan 1 , David D. Shin 2 , Chi-Jen Chen 1 , Thomas T. Liu 2 , and Ho-Ling Liu 3

1 Department of Radiology, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan, 2 Center for Functional MRI and Department of Radiology, University of California, San Diego, La Jolla, CA, United States, 3 Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan

This study aimed to investigate the perfusion-based modular architecture for the bilateral anterior, middle, and posterior cerebral artery (ACA, MCA, and PCA) territories, and default mode network (DMN). Whole-brain CBF maps from 116 healthy subjects, based on arterial spin labeling measurements, were included for the analysis. Brain regions exhibited significantly correlated CBF variations among subjects were identified by comparing each area in the AAL template with the seed region. The results demonstrated that significant short- and long-range connections were found in these territories and DMN. This study provides a preliminary result of intrinsic CBF modularity of the human brain.

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