Deoxyhemoglobin and hypercapnia based fMRI calibration methods
Yongxia Zhou 1 , Zachary B Rodgers 1 , and Felix W Wehrli 1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States
Our objective was to compare the fMRI calibration
parameter (M) quantified with two methods and to
establish a mutual scaling factor. Deoxyhemoglobin based
calibration was achieved by quantifying R2 to yield
MR2 after magnetic field inhomogeneity correction.
Calibration exploiting the fractional change in cerebral
blood flow during hypercapnia was obtained by ASL,
providing along with the measured change in BOLD
Mhypercapnia via Davis model. Preliminary results show
comparable calibration M values for the two methods. The
quantitative scaling factor might provide potential
support for the R2 calibration method, which is more
straightforward to implement.
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