Associations of Resting-State fMRI Functional Connectivity with Flow-BOLD Coupling and Regional Vasculature
Sungho Tak 1 , Danny J. J. Wang 2 , Jonathan R. Polimeni 3 , Lirong Yan 2 , and J. Jean Chen 1
Rotman Research Institute at Baycrest
Centre, Toronto, ON, Canada,
of Functional MRI Technology (LOFT), University of
California, Los Angeles, CA, United States,
A. Martinos Center for Biomedical Imaging, Harvard
Medical School, Charlestown, MA, United States
In this study, we investigated regional associations of
resting-state functional connectivity MRI (fcMRI)
estimates with cerebral blood flow (CBF)-BOLD coupling,
as well as the role of large vessel volume. Based on
extensive analyses, we found that functional
connectivity strength was significantly proportional to
the regional strength in CBF-BOLD coupling, and
inversely proportional to large-vessel volume fraction.
Our work suggests that despite inherent ambiguity of
fcMRI estimates, synchronized activities observed in the
functional networks are not likely to be mediated by
common vascular drainage linking distal cortical areas,
but rather by tighter CBF-BOLD coupling, which might be
associated with neuronal connection.
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