Abstract #4215
Cerebral Blood Volume Contribution to the Functional T1ρ in the Human Brain
Hye-Young Heo 1 , Casey P Johnson 1 , Daniel R Thedens 1 , John A Wemmie 2,3 , and Vincent A Magnotta 1,3
1
Department of Radiology, University of Iowa,
Iowa City, Iowa, United States,
2
Department
of Neurosurgery, University of Iowa, Iowa, United
States,
3
Department of Psychiatry, University
of Iowa, Iowa, United States
Recent experiments suggest that functional imaging of T1
relaxation in the rotating frame (T1ρ) can detect
localized metabolic changes in the human visual cortex
induced by a flashing checkerboard task. Possible
sources of the functional T1ρ signal include changes in
pH, glucose and glutamate concentrations, and cerebral
blood volume. In this study we explored the relationship
between the functional T1ρ signal and cerebral blood
volume by employing an inferior saturation pulse. The
results show that, although there is a contribution of
cerebral blood volume to the functional T1ρ signal, a
majority of the signal likely comes from the tissue
compartment. Therefore, using spatial saturation pulses
is an effective and efficient means to minimize blood
volume contributions to the functional T1ρ signal.
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