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Abstract #4217

Comparing the microvascular specificity of the 3 T and 7 T BOLD response

Simon Daniel Robinson 1 , Florian Fischmeister 1,2 , Gnther Grabner 1 , Moritz Wurnig 1,2 , Jakob Rath 1,2 , Thomas Foki 1,2 , Eva Matt 1,2 , Siegfried Trattnig 1 , Roland Beisteiner 1,2 , and Alexander Geissler 1,2

1 Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Vienna, Austria, 2 Department of Neurology, Medical University of Vienna, Vienna, Austria

The specificity of the BOLD response to microvascular rather than draining vein signal is understood to increase with field strength. This understanding is based on image SNR and relaxation rates, however. In the light of recent studies showing less than linear increases of time-series SNR and activation statistics with field strength we re-examined the specificity of the BOLD response in high resolution fMRI at 3T and 7T with 12 subjects who performed a hand task. fMRI data were analysed with ICA and compared with 7T SWI. There was a significant increase in sensitivity but not specificity with field strength.

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