Oscillating gradient diffusion MRI reveals frequency-dependent contrasts in cellular layers of the human cerebellum
Manisha Aggarwal 1 and Susumu Mori 1
Department of Radiology, Johns Hopkins
University School of Medicine, Baltimore, MD, United
We investigate the effect of gradient frequency on
diffusion MR contrasts derived using oscillating
diffusion-sensitizing gradients in the fixed human
cerebellum. Using diffusion MRI data acquired at 11.7 T
with pulsed gradient and modified trapezoid-cosine
oscillating gradient waveforms (at frequencies of 67,
100, 150, and 200 Hz), we report the generation of
unique layer-specific contrasts in the human cerebellum.
Quantitative maps derived from the rate of change in ADC
measurements with gradient frequency revealed distinct
anatomical contrasts highlighting specific cerebellar
layers, which were compared with histologically-stained
sections of the same tissue. The results demonstrate the
potential of oscillating-gradient diffusion MRI
acquisitions to generate anatomical contrasts that are
sensitive to the microstructure of cellular layers in
the human cerebellar gray matter.
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