Correcting for B1 inhomogeneities in post-mortem DWSSFP human brain data at 7T using multiple flip angles
Sean Foxley 1 , Saad Jbabdi 1 , Stuart Clare 1 , and Karla Miller 1
FMRIB Centre, University of Oxford, Oxford,
OXON, United Kingdom
Due to the comparably sized RF wavelength at 7T, human
brain imaging suffers from a central bright spot.
Here, we investigated the implementation of a multiple
flip angle approach to account for this B1 dependent
artifact. Data were acquired at 7T of post-mortem human
brain using a diffusion weighted steady-state free
precession pulse sequence. Two flip angles were chosen
using a described optimization method and DTI data were
acquired using both. Results demonstrate that the
primary diffusion direction was more accurately
estimated in gray matter where signal loss due to B1
decreases have made this otherwise difficult to detect.
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