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Abstract #4455

Probing white matter microstructure at high spatial resolution combining CHARMED protocol optimization and a high performance gradient set

Matteo Bastiani 1 , Silvia De Santis 2,3 , Derek Jones 2,3 , Yaniv Assaf 4 , and Alard Roebroeck 1

1 Department of Cognitive Neuroscience, Maastricht University, Maastricht, Limburg, Netherlands, 2 CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 3 Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom, 4 Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

The composite hindered and restricted model of diffusion (CHARMED) typically requires multiple acquisitions with high b-values and high angular resolution, both of which are difficult to obtain with clinical MRI systems. The purpose of this study is to investigate the feasibility of probing white matter microstructure at high spatial resolution in vivo at 3T, combining protocol optimization and a high amplitude, high slew-rate gradient set. Different levels of trade-off between resolution, SNR and diffusion contrast are compared and the results are further compared to a benchmark dataset obtained from the Human Connectome Project (HCP).

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