Abstract #4457
Effect of Diffusion Time on Intravoxel Incoherent Motion Parameters in Abdominal Organs
Yeeliang Thian 1 , Matthew R. Orton 2,3 , David J. Collins 2,3 , James A. d'Arcy 2,3 , Martin O. Leach 2,3 , Thorsten Feiweier 4 , and Dow-Mu Koh 1
1
Department of Radiology, Royal Marsden
Hospital, Sutton, Surrey, United Kingdom,
2
CR-UK
and EPSRC Cancer Imaging Centre,Institute of Cancer
Research UK, Surrey, United Kingdom,
3
Royal
Marsden Hospital, Surrey, United Kingdom,
4
Siemens
AG, Healthcare Sector, Erlangen, Germany
The intra-voxel incoherent motion (IVIM) model relates
signal decay on diffusion-weighted MRI (DWI) to tissue
characteristics of perfusion and diffusivity. We
explored the effects of altering the diffusion time of
DWI sequences on IVIM perfusion (f,D*) and diffusion (D)
related parameters in abdominal organs of healthy
volunteers. At longer diffusion times, the calculated
perfusion fraction (f) was significantly increased while
the effect on the D and D* parameters was more variable,
depending on the organ under study. The diffusion time
has a significant impact on measured IVIM parameters in
abdominal organs and should be reported when employing
the IVIM model.
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