Abstract #4487
Rotation-invariant measures for population study in HARDI
Emmanuel Caruyer 1 and Ragini Verma 1
1
Section of Biomedical Image Analysis,
Department of Radiology, University of Pennsylvania,
Philadelphia, PA, United States
We present a novel family of rotational-invariant
measures for High Angular Resolution Diffusion Imaging1
(HARDI) data. This research is motivated by need for the
developing new biomarkers and thereby facilitating
population-based studies in HARDI. From a spherical
harmonics (SH) representation of the angular information
in diffusion MRI, we derive 12 rotational-invariant
measures computed as homogeneous polynomials of the SH
coefficients. These measures are expected to be
sensitive to subtle changes in white matter structure,
not captured by FA or GFA. The large number of measures
will be used to create population classifiers, paving
the way for pathology-specific biomarkers.
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