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Abstract #4491

Analysis of the cumulant expansion terms of the diffusion-weighted MRI signal in the human brain

Ezequiel Farrher 1 , Farida Grinberg 1,2 , Ivan I. Maximov 1 , and N. Jon Shah 1,2

1 INM - 4, Research Centre Jlich GmbH, Jlich, Germany, 2 Department of Neurology, RWTH Aachen University, Aachen, Germany

Diffusion kurtosis imaging has become an important extension to diffusion tensor imaging in the quantification of non-Gaussian diffusion by means of magnetic resonance imaging. However, there is still no general consensus on the optimal range of b-values for data analysis. In this work we perform an investigation on the dependence of the cumulant expansion terms of the diffusion-weighted MRI signal on the fitting b-value range. The present analysis gives important insights into the validity of the fitting b-value range in DKI analysis.

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