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Abstract #4492

Improving fiber orientation estimation in constrained spherical deconvolution under non-white matter partial volume effects

Timo Roine 1 , Ben Jeurissen 1 , Wilfried Philips 2 , Alexander Leemans 3 , and Jan Sijbers 1

1 iMinds-Vision Lab, University of Antwerp, Antwerp, Flanders, Belgium, 2 Department of Telecommunications and Information Processing, University of Ghent, Ghent, Flanders, Belgium, 3 Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands

Diffusion-weighted magnetic resonance imaging is prone to large partial volume effects (PVEs) due to its large voxel size. In this work, we studied the PVEs with non-white matter (WM) tissue on estimation of the fiber orientation distribution function (fODF) with constrained spherical deconvolution (CSD). We found a loss of precision in the detected fiber orientations and an emergence of a high number of false orientations in the fODF. The effects were most significant with gray matter (GM) partial volume. We propose a modification to CSD to further improve the estimation of the fODF especially near the WM-GM interface.

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