Abstract #4494
Altered Global and Regional Brain Mean Kurtosis in Recently-Diagnosed Patients with Obstructive Sleep Apnea
Rajesh Kumar 1 , Santosh K Yadav 1 , Jennifer A Ogren 2 , Mary A Woo 2 , Daniel W Kang 3 , Paul M Macey 2 , Frisca L Yan-Go 4 , and Ronald M Harper 5
1
Anesthesiology, University of California at
Los Angeles, Los Angeles, CA, United States,
2
UCLA
School of Nursing, University of California at Los
Angeles, Los Angeles, CA, United States,
3
Medicine,
University of California at Los Angeles, Los Angeles,
CA, United States,
4
Neurology,
University of California at Los Angeles, Los Angeles,
CA, United States,
5
Neurobiology,
University of California at Los Angeles, Los Angeles,
CA, United States
Obstructive sleep apnea (OSA) patients show structural
injury and functional deficits in multiple brain areas,
based on various MRI techniques, in sites that regulate
autonomic, motor, cognitive, and mood functions,
deficient in the condition. However, the nature of
tissue injury remains unclear. We examined global and
regional mean kurtosis values in newly-diagnosed,
treatment-naive OSA patients, and found increased global
values in critical autonomic, cognitive, motor, and
respiratory control sites, including the insular
cortices, cerebellum, and basal-ganglia. The
pathological mechanisms contributing to tissue injury
likely include hypoxemia-induced processes, leading to
acute tissue changes in OSA.
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