Enhanced Contrast of Ischemic Stroke Lesions in Non-Gaussian Diffusion Imaging
Farida A. Grinberg 1 , Ezequiel Farrher 1 , Luisa Ciobanu 2 , Franoise Geffroy 2 , Denis Le Bihan 2 , and N. Jon Shah 1,3
Forschungszentrum Juelich, Juelich, Germany,
Aachen University, Germany
We compare a sensitivity of two non-Gaussian diffusion
models with the gold standard ADC approach in providing
the contrast for ischemic lesions in animals: the
stretched-exponential and gamma-distribution functions.
Both functions provide good fits in the extended range
of the diffusion weightings and allow for an enhanced
contrast of the lesions. An interesting finding of this
work is the appearance of laminar cortical structures in
stroke lesions clearly visualised by the parameter maps
of the investigated models but hardly observable in the
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