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Abstract #4541

Sensitivity and specificity of prostate tumor discrimination by IVIM approximation

Gina Belmonte 1 , Vito Biondo 2 , Augusto La Penna 3 , Francesco Carbone 4 , Gianluca Vischi 5 , Leonardo Semeraro 5 , and Fabrizio Banci Buonamici 1

1 Medical Physics, University Hospital of Siena, Siena, Italy, Italy, 2 University of Siena, Italy, Italy, 3 Radiology, University of Siena, Italy, Italy, 4 Radiology, University Hospital of Siena, Italy, Italy, 5 Radioterapy, University of Siena, Italy, Italy

We analyzed precision and accuracy in the discrimination of prostate tumor of IVIM parameters measured with a bi-exponential fit and a simplified approach, that allows to estimate the diffusion coefficient and the pseudo-diffusion fraction from a 2 b-values acquisition. ROC analysis were used to extract the optimum cut-off for each parameter that maximize the accuracy of test. The simplified IVIM parameters are not accurate estimates of the corresponding ones from the bi-exponential fit, but discriminate prostate tumor from healthy tissues in a accurate way. This simplified technique allows therefore to reduce the acquisition time and preserve a good diagnostic accuracy.

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