Effects of gradient nonlinearity correction on DTI ADC and FA measurements for assessing breast cancer treatment response
David Newitt 1 , Ek Tsoon Tan 2 , Lisa Wilmes 1 , Hee Jung Shin 3 , Luca Marinelli 2 , and Nola Hylton 1
Radiology and Biomedical Imaging, UCSF, San
Francisco, CA, United States,
Global Research, Niskayuna, NY, United States,
Asan Medical Center, University of Ulsan, Korea
Gradient nonlinearity (GN) is a significant source of
error for quantitative diffusion MRI and is of
particular concern in breast imaging where anatomy
requires large offsets from magnet isocenter. GN
correction (GNC) to correct for spatially-varying
diffusion encoding was evaluated in DTI acquired ADC and
FA of tumor and normal tissue regions in breast cancer
subjects undergoing neoadjuvant chemotherapy. GNC
resulted in a mean change in tumor ADC of -11% (range
-4% to -19%), and in FA of -6% (range -24% to 20%).
Percent change in tumor ADC between visits had an RMS
change of 3% with GNC.
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