What Is the Ideal Labeling Duration for Pseudocontinuous Arterial Spin Labeling?
Zungho Zun 1 , R. Marc Lebel 2 , Ajit Shankaranarayanan 3 , and Greg Zaharchuk 1
Stanford University, Stanford, CA, United
Healthcare, Calgary, AB, Canada,
Healthcare, Menlo Park, CA, United States
A recent arterial spin labeling (ASL) white paper
recommends pseudocontinuous ASL (PCASL) with labeling
duration (LD)/post-labeling delay (PLD) of 1.8/2.0 s for
clinical applications. Compared to PLD, there has been
little exploration in optimization of LD. In this study,
CBF measurement was performed in volunteers using PCASL
with different LD, and ASL signal-to-noise ratio (SNR)
efficiency was compared among scans with different LD.
Measured SNR efficiency showed good agreement with
simulation and was maximized when LD was 3-4 s,
achieving about 30% gain compared to LD = 1.5 s.
Potential reduction in apparent CBF measurement with
prolonged LD was not found.
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