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Abstract #4576

Brainstem Cerebral Blood Flow in Women with Poly-Cystic Ovary Syndrome (PCOS)

Esther A. H. Warnert 1 , Andrew Lansdown 2 , Kevin Murphy 1 , Judith E. Hall 3 , D. Aled Rees 2 , and Richard G. Wise 1

1 CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2 Centre for Endocrine and Diabetes Sciences, Institute of Experimental and Molecular Medicine, School of Medicine, Cardiff University, United Kingdom, 3 Department of Anaesthetics and Intensive Care Medicine, School of Medicine, Cardiff University, United Kingdom

This abstract contains preliminary results of a clinical study investigating brain function and physiology in women suffering from Poly-Cystic Ovary Syndrome (PCOS). Here, we focus on the brainstem (and the medulla in particular), because of the recent finding that a potential marker of PCOS is hyperactivity of the sympathetic nervous system, in which nuclei in the medulla play a central role. Arterial spin labelling is used to assess differences in brainstem cerebral blood flow between PCOS patients and healthy controls.

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