DECREASED CEREBRAL BLOOD FLOW AND CO2 REACTIVITY IN HEALTHY AGING: A PULSED ASL STUDY
Renata Ferranti Leoni 1,2 , Icaro Agenor Ferreira de Oliveira 1 , Octavio Marques Pontes Neto 2 , and Joo Pereira Leite 2
Department of Physics - FFCLRP, University
of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil,
of Neuroscience and Behavioral Sciences - FMRP,
University of Sao Paulo, Ribeirao Preto, Sao Paulo,
Altered cerebral perfusion has been observed in normal
aging. To understand these alterations it is important
to comprehend age-related neurological disorders. In
this study, pulsed arterial spin labeling and
hypercapnia were used to investigate regional cerebral
blood flow (CBF) and cerebrovascular reactivity (CVR) in
elderly healthy volunteers. Decreased CBF and CVR were
observed across the entire cerebral cortex in elderly
subjects compared to young subjects. This reduction may
be related to arteriosclerosis and small vessel disease.
Further studies may use the same protocol to investigate
brain areas vulnerable to neurological disorders due to
impaired vascular reserve.
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