Dynamic Contrast Enhanced (DCE)-MRI and Circulating Angiogenic Factors for Monitoring of Antiangiogenic Effect of Bevacizumab in Colorectal Cancer Liver Metastasis
Bio Joo 1 , Mi-Suk Park 1 , Yeo-Eun Kim 1 , and Sang-Joon Shin 2
Department of Radiology and Research
Institute of Radiological Science, Yonsei University
College of, Seoul, Korea,
Metastasis Research Center, Yonsei University College of
Medicine, Seoul, Korea
We assessed the clinical outcomes of colorectal cancer
liver metastasis (CRCLM) patients treated with
Bevacizumab plus FOLFOX by Dynamic Contrast Enhanced
(DCE)-MR imaging and plasma cytokines and angiogenic
factors (CAFs). Significant changes in DCE-MRI and CAFs
on 3 day after bevacizumab monotherapy proved
anti-angiogenic effect of bevacizumab monotherapy.
Higher baseline iAUC60 and early reduction of Ktrans
could predict longer PFS in the patients with CRCLM.
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