Abstract #4592
Bias and precision of three different DCE-MRI analysis software packages: a comparison using simulated data
Greg O Cron 1,2 , Steven Sourbron 3 , Daniel P Barboriak 4 , Rhys Abdeen 2 , Matthew Hogan 2,5 , and Thanh B Nguyen 1,2
1
Medical Imaging, Ottawa Hospital Research
Institute, Ottawa, Ontario, Canada,
2
University
of Ottawa, Ottawa, Ontario, Canada,
3
Institute
of Genetics, Health, and Therapeutics, University of
Leeds, Leeds, United Kingdom,
4
Radiology,
Duke University Medical Center, Durham, North Carolina,
United States,
5
Neuroscience, Ottawa Hospital
Research Institute, Ottawa, Ontario, Canada
Software packages (SPs) for analysis of DCE-MRI data
abound. However, it is unclear how consistent they are
with each other, which impedes standardization. The
purpose of this work was to compare three DCE-MRI SPs,
using identical simulated data, to see if the SPs have
different bias and precision. We observed differences
between the SPs, especially in terms of how they react
to noise. These results support the notion that the bias
and precision of a DCE-MRI analysis may be affected by
the particular SP used. In conclusion, only a single SP
should be used for a given DCE-MRI study.
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