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Abstract #4595

Implications of unequal interstitium and plasma contrast reagent relaxivities in pharmacokinetic analysis of DCE-MRI

Xin Li 1 , Yu Cai 1 , Brendan Moloney 1 , Wei Huang 1 , Mark G. Garzotto 2,3 , Mark Woods 1 , and Charles S Springer 1

1 Advanced Imaging Research Center, Oregon Health & Science University, Portland, Oregon, United States, 2 Portland VA Medical Center, Portland, Oregon, United States, 3 Urology, Oregon Health & Science University, Portland, Oregon, United States

In Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI), contrast reagent (CR) concentration is linearly related to water R1 change for a single compartment. The longitudinal relaxivity quantifies the CR potency to change water proton T1. It is current practice to assume that the longitudinal relaxivities are the same in blood plasma and all interstitial compartments. However, there is evidence suggesting a potential increase in the interstitium longitudinal relaxivity. Based on human prostate data, we demonstrate the implications of unequal interstitium and plasma relaxivity values on DCE-MRI pharmacokinetic parameters.

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