Meeting Banner
Abstract #4616

Assessment of Brain Damage and Plasticity in the Visual System after Early Occipital Injury: Comparison of FDG-PET with Diffusion MRI Tractography

Jeong-Won Jeong 1 , Joseph Shin 2 , Vijay N Tiwari 2 , Harry T Chugani 1 , and Csaba Juhasz 1,2

1 Pediatrics and Neurology, Wayne State University, Detroit, Michigan, United States, 2 PET center, Children's Hospital of Michigan, Detroit, Michigan, United States

The present study combined DWI streamline tractography with FDG-PET to determine the relation between occipital cortical metabolic changes and abnormalities of the corresponding visual tracts in children with unilateral Sturge-Weber syndrom (SWS). We found that decreased occipital glucose metabolism is associated with decreased visual streamline volume on the affected hemisphere. We also found that high glucose metabolism in the contralateral occipital (visual) cortex is associated with high DWI streamline volume of the corresponding visual pathway. This study demonstrates that FDG-PET combined with DWI tractography can be utilized to investigate both brain damage and plasticity in children with early occipital lesion.

This abstract and the presentation materials are available to members only; a login is required.

Join Here