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Abstract #4627

Effects of craniosynostosis on cerebral blood flow

Dustin K Ragan 1 , Gary Skolnick 2 , Jose A Pineda 1 , Matthew D Smyth 3 , and Kamlesh Babulal Patel 2

1 Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States, 2 Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States, 3 Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, United States

Craniosynostosis is associated with elevated ICP, however its physiological effects are largely unknown. We studied the effects of craniosynostosis on cerebral perfusion using pseudocontinuous ASL. Focal regions of apparent hyperemia were detected, suggesting either metabolic abnormalities or a decrease in CSF space.

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