Catechol-O-methyl transferase Val108/158Met genotype influences the striatum volume in healthy subjects: A voxel-based morphometry study at 3T MRI.
Keita Watanabe 1 , Shingo Kakeda 1 , Reiji Yoshimura 2 , Abe Osamu 3 , Ide Satoru 1 , Rieko Watanabe 1 , Asuka Katsuki 2 , Wakako Umene-Nakano 2 , Jun Nakamura 2 , and Yukunori Korogi 1
Radiology, University of Occupational and
Environmental Health, Fukuoka, Japan, Kitakyushu,
University of Occupational and Environmental Health,
Fukuoka, Japan, Japan,
University School of Medicine, Tokyo, Japan
Catechol-O-methyltransferase (COMT) is a methylation
enzyme engaged in the degradation of dopamine by
catalyzing the transfer of a methyl group from
S-adenosylmethionine. Although COMT appears to be
concentrated especially in the prefrontal cortex (PFC)
and medial temporal lobe, the recent studies showed that
COMT impact on brain activation is not limited to the
PFC and medial temporal lobe, but extending into the
striatum in healthy subjects. We investigated the
relationship between the Val108/158Met COMT genotype and
striatum volume. We found that COMT genotype affects the
caudate volume,which may relate to the differences of
dopamine level in the striatum.
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