Quantification of the Cerebellar Lobe Volumes using a 2D T2 TSE PROPELLER Sequence: Reliability Analysis.
Marco Piccirelli 1 , Alexander A. Tarnutzer 2 , Werner Wichmann 1 , Antonios Valavanis 1 , Dominik Straumann 2 , and Franziska C.S. Altorfer 1
Neuroradiology, University Hospital Zurich,
Zurich, ZH, Switzerland,
University Hospital Zurich, Zurich, ZH, Switzerland
Cerebellar volumetry correlates multiple clinical
findings (ataxia, seizures, psychiatric symptoms) with
localized cerebellar atrophy. Therefore, researchers
quantified the volume of cerebellar parts using
high-resolution 3D-T1-SPGR sequences, which has an
intrinsic low CSF/GM contrast and is motion-sensitive.
Nevertheless, the coarse volumetry reported in clinical
studies is corrupted by the low resolution of clinical
3D-T1-SPGR. To avoid artifacts, we propose an
intrinsically motion insensitive PROPELLER 2D-T2-TSE to
clearly depict cerebellar borders and quantify
cerebellar lobe volumes. These results set the basics
for a clinically useable quantification of cerebellar
atrophy and give a reference to further volumetric
analysis of individual cerebellar lobes.
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