Investigation of normal brain aging in rodent experimental model by DTI, Volumetry and localized proton spectroscopy
Stefano Tambalo 1 , Alessandro Daducci 2 , Elisa Mosconi 1 , Silvia Fiorini 1 , Nicolo' Sonato 1 , Marta Balietti 3 , Patrizia Fattoretti 3 , Andrea Sbarbati 4 , and Pasquina Marzola 5
Dept. of Neuological and Movement Science,
Universit di Verona, Verona, Verona, Italy,
IEL LTS5, EPFL, Lausanne, Switzerland,
of Aging Laboratory and Cellular Bioenergetics
Laboratory, I.N.R.C.A. (Italian National Centres on
Aging), Ancona, Italy,
of Neuological and Movement Science, INSTM Firenze,
of Computer Science, University of Verona, Verona, Italy
In the last decade many studies of human brain aging
based on MRI advanced techniques have been published.
Clinical studies are potentially affected by several
factors, such as life-style or genetic variability.
Experimental models of aging could be useful in
dissecting physiological from pathophysiological events
as well as the impact of environmental or genetic
factors. They could also represent a platform to study
the effect of pharmacological and non-pharmacological
therapies in delaying brain aging. Aim of present work
was the investigation of brain aging in a rodent
experimental model by advanced MRI techniques and the
assessment of its potential translational value.
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