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Abstract #4675

Increased grey matter transit times are associated with white matter hyper intensities

Jan Willem van Dalen 1 , Henri J M M Mutsaerts 2 , Lisa S M Eurelings 1 , Martijn D Steenwijk 3 , Hugo Vrenken 3 , Matthan W A Caan 2 , Aart J Nederveen 2 , and Edo Richard 1

1 Neurology, Academic Medical Center, Amsterdam, Noord Holland, Netherlands, 2 Radiology, Academic Medical Center, Amsterdam, Noord Holland, Netherlands, 3 Radiology and Nuclear Medicine, VU University Medical Center, Noord Holland, Netherlands

White matter hyper intensities of presumed vascular origin (WMH) are a common finding on brain MRI in the elderly, associated with hypertension, cognitive decline and mortality. Although they are thought to arise from low grade ischemia, the relation between WMH load and cerebral blood flow (CBF) remains to be fully elucidated. In this study, WMH and CBF data, including transit time, were obtained from 3D FLAIR and pCASL (including vascular crushing) MRI scans of 196 community dwelling elderly with systolic hypertension. Unlike total and crushed CBF, grey matter transit time was significantly associated with increasing WMH load.

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