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Abstract #4677

Brain Iron Content and Smoking History in Healthy Older Individuals

Yosef A Berlow 1,2 , David L Lahna 3 , Daniel L Schwartz 4 , Randall L Woltjer 5 , Robin L Guariglia 3 , Lisa C. Silbert 3 , Jeffrey A Kaye 3 , and William D Rooney 1,2

1 Advanced Imaging Research Center, Oregon Health & Science University, Portland, Oregon, United States, 2 Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, United States, 3 Department of Neurology, Oregon Health & Science University, Portland, Oregon, United States, 4 Department of Psychiatry, Oregon Health & Science University, Portland, Oregon, United States, 5 Department of Pathology, Oregon Health & Science University, Portland, Oregon, United States

Cigarette smoking has been demonstrated to significantly alter systemic iron metabolism. This study utilized R 2 measurements from MRI scans of 81 healthy elderly individuals to investigate the relationship between smoking history and MRI measures of brain iron content using a region of interest analysis. Individuals with long-term smoking histories were found to have increased R 2 values in the caudate and putamen compared to aged-matched nonsmokers and individuals with short-term smoking histories. Increased R 2 values were correlated with pack year history in the caudate. These findings suggest that smoking cigarettes may increase lifetime brain iron accumulation in these basal ganglia structures.

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