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Abstract #4683

Diffusion kurtosis metrics as biomarkers of microstructural development: a comparative study of a group of children and a group of adults

Farida A Grinberg 1,2 , Ivan I Maximov 1 , Ezequiel Farrher 1 , Irene Neuner 1,3 , Laura Amort 1,4 , Heike Thnneen 1,5 , Kerstin Konrad 6,7 , and N. Jon Shah 1,8

1 INM-4, Forschungszentrum Juelich, Juelich, Germany, 2 Department of Neurology, RWTH Aachen University, Aachen, Germany, 3 Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Germany, 4 Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, 5 Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Germany, 6 Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany, 7 Institute of Neuroscience and Medicine 3, Forschungszentrum, Germany, 8 Department of Neurology, RWTH Aachen University, Germany

Recently, diffusion kurtosis imaging (DKI) has become interesting as an efficient method for characterising non-Gaussian water diffusion in brain tissue. In this work, we used DKI to evaluate and compare water diffusion properties in the whole brain and in anatomically defined regions in a group of children and in a group of adults. An intergroup comparison using TBSS and averaged atlas-based regional data analysis shows that DKI metrics are significantly more sensitive to age related microstructural changes than conventional DTI.

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