A selective ageing effect on the frontal lobe connections
Michel Thiebaut de Schotten 1,2 , Katrine Rojkova 1 , Marika Urbanski 1 , Frederic Humbert 1 , Flavio Dell'Acqua 2 , and Emmanuelle Volle 1
Brain and Spine Institute, Paris, France,
- Institute of Psychiatry, London, United Kingdom
Cognitive decline affects predominantly executive
functions, and brain changes seem to distribute
unevenly, concerning predominantly the frontal region.
Hence, the study of the frontal connections is of
particular interest for the neurosciences of ageing.
Here our results suggest for the first time that aging
alters significantly specific long and short tracts in
the frontal lobes which brings up interesting hypotheses
on a pathophysiological explanation for aging decline in
visuospatial and verbal working memory, memory encoding
and retrieval, reward-based associative learning that
can be tested in the elderly.
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