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Abstract #4719

Preliminary Diffusional Kurtosis Imaging of the substantia nigra in de novo Parkinson disease: Diagnostic Utility of Histogram Analysis

Koji Kamagata 1 , Masaaki Hori 1 , Kohei Kamiya 1 , Michimasa Suzuki 1 , Akira Nishikori 2 , Mariko Yoshida 1 , Fumitaka Kumagai 2 , Taku Hatano 3 , Hiroyuki Tomiyama 3 , Nobutaka Hattori 3 , and Shigeki Aoki 1

1 Department of Radiology, Juntendo University School of Medicine, Tokyo, Bunkyo-ku, Japan, 2 Department of Radiological Sciences, Tokyo Metropolitan University, Tokyo, Japan, 3 Department of Neurology, Juntendo University School of Medicine, Tokyo, Bunkyo-ku, Japan

We preliminarily investigated the efficacy of analyzing histograms of diffusional kurtosis imaging metrics to diagnose Parkinson disease (PD) in vivo. The mean and median values of FA and MK in the substantia nigra pars compacta (SNpc) were significantly lower in PD patients than in healthy controls (MannWhitney U test with Bonferroni correction). The median MK in the SNpc showed the best diagnostic performance (mean cutoff, 0.910; sensitivity, 0.93; specificity, 0.83). Our results demonstrate that histogram analysis of MK measurements can be a useful tool to diagnose PD in vivo.

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