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Abstract #4720

Diffusion Tensor Imaging Studies Support Pre-symptomatic Degeneration of Selective Axonal Fibers in a Mouse Model of Amyotrophic Lateral Sclerosis (Lou Gehrigs disease).

Rodolfo Gatto 1 , Weiguo Li 2 , Ehsan Tavassoli 1 , Andrea Buenaventura 1 , William Hendrickson 3 , Gerardo Morfini 1 , and Richard Magin 2

1 Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois, United States, 2 Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, United States, 3 Research Resource Center, University of Illinois at Chicago, Chicago, Illinois, United States

Amyotrophic lateral Sclerosis (ALS) is characterized by progressive degeneration and eventual death of motor neurons in the spinal cord. Among several mutant SOD1 mouse models generated, G93A-SOD1 represent the best-characterized one. The remarkable correspondence in clinical phenotype observed between G93A-SOD1 mice and human ALS made this model a benchmark for pre-clinical screening of ALS therapies. As a step towards this end, we performed correlative diffusion tensor imaging (DTI) and histological studies in white (WM) and grey (GM) matter of spinal cords obtained from pre-symptomatic G93A-SOD1 mice and wild-type (control, WT-SDO1) mice

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