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Abstract #4723

Longitudinal Changes in Glutamate in a Mouse Model of Tauopathy Measured by GluCEST

Rachelle Crescenzi 1,2 , Catherine DeBrosse 1,2 , Ravi Prakash Reddy Nanga 2 , Kevin D'Aquilla 2 , Hari Hariharan 2 , Ari Borthakur 2 , Virginia M.-Y. Lee 3 , and Ravinder Reddy 2

1 Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA, United States, 2 Center for Magnetic Resonance and Optical Imaging (CMROI), University of Pennsylvania, Philadelphia, PA, United States, 3 Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania, Philadelphia, PA, United States

Glutamate is a wide-spread excitatory neurotransmitter, and has been shown by magnetic resonance spectroscopy (MRS) to decrease in the hippocampus of Alzheimers disease patients. Here we have studied this quickly progressing mouse model longitudinally, using GluCEST and 1H MRS to measure the effects of progressive tau pathology on glutamate levels. Glutamate increases during neuronal development of adolescent mice, and decreases in the thalamus/hypo-thalamus with the progression of tau pathology. In two cases, extremely low GluCEST values predicated early disease onset.

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