Abstract #4734
Mean diffusivity measurement in gray matter: a potential image-based biomarker of MCI and AD
Sung-han Lin 1 , Wen-Chiun Hsu 2,3 , Yao-Liang Chen 4 , and Jiun-Jie Wang 5,6
1
Graduate Institute of Clinical Medicine,
Chang Gung University, Taoyuan County, Taiwan,
2
Department
of Neurology, ChangGung Memorial Hospital, Linkou,
Taoyuan County, Taiwan,
3
Dementia
Center, Chang Gung Memorial Hospital, Linkou, Taoyuan
County, Taiwan,
4
Department
of Medical Imaging and Intervention, Chang Gung Memorial
Hospital, Linkou, Taoyuan County, Taiwan,
5
Department
of Medical Imaging and Radiological Sciences, Chang Gung
University, Taoyuan County, Taiwan,
6
Neuroscience
Research Center, Chang Gung Memorial Hospital, Linkou,
Taoyuan County, Taiwan
The changes of mean diffusivity in cortical gray matter
were compared among 121 participants, divided into three
groups: healthy, mild cognitive impairment and
Alzheimers disease. The percentage changes in frontal
and temporal lobes between Alzheimers disease and
healthy is approximately equal to that in Alzheimers
disease with mild cognitive impairment and mild
cognitive impairment with healthy. The involved regions
of Alzheimers disease are overlapped with that by mild
cognitive impairment and normal. Combining the changes
and involved regions of mean diffusivity, it could be
suggested that mild cognitive impairment is a transition
stage between healthy and Alzheimers disease.
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