Regional White Matter disruption within the Corpus Callosum in patients with Mild Cognitive Impairment Single and Multiple domain
Elena Makovac 1 , Barbara Span 1 , Laura Serra 1 , Giovanni Giulietti 1 , Mario Torso 1 , Mara Cercignani 1,2 , Carlo Caltagirone 3,4 , and Marco Bozzali 1
Neuroimaging Laboratory, IRCCS Santa Lucia
Foundation, Rome, Italy,
Imaging Sciences Centre, Brighton and Sussex Medical
School, United Kingdom,
of Neuroscience, University of Rome Tor Vergata, Rome,
of Clinical and Behavioural Neurology, IRCCS Santa Lucia
Foundation, Rome, Italy
Two main clinical subtypes of amnestic MCI has been
described, single-domain and multiple-domain aMCI In the
present study we examined the Corpus Callosum (CC) by
applying DTI-based tractography in SDamci and MDamci.
Using a vixel-based approach, we were able to delineate
a precise direction of WM damage inside the CC, starting
from the Splenium in SDamci and proceeding toward the
Genu in the MDamci, and eventually declining in a
general CC WM damage in the final AD stage. These
findings clarify some relevant aspects of AD
pathophysiology and provide information of potential
prognostic value for disease monitoring.
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